Neuroprotection role of cooling helmet on neuron specific enolase (NSE) and post-surgery delirium levels in open heart surgery patients: a randomized controlled trial

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چکیده

Background & objective: This study aims to assess the effect of cooling helmet during surgery on neuron specific enolase (NSE) and delirium levels following open heart patients with cardiopulmonary bypass (CPB) using a heart-lung machine.
 Methodology: double-blind randomized clinical trial took place from October December 2021 in tertiary care hospital. The research used modified decrease brain temperature. Inclusion criteria were adult who scheduled for CPB. subjects into two groups: as treatment group (n = 12) non-cooling control 13). differences between NSE both groups assessed at times.
 Results: lower than (7.13 ± 7.63 vs. 12.49 6.81; P < 0.05). Regarding delirium, no statistically significant difference was found (P > 0.05).
 Conclusion: hypothermia is associated levels, but it did not significantly correlate prevent after Abbreviations: CABG: coronary artery graft; CPB: Cardiopulmonary Bypass; CMRO2: cerebral metabolic rate oxygen; HLM: Heart-lung machine; NSE: Neuron Specific Enolase; ROS: reactive oxygen species
 Citation: Adji MP, Hidayat JK, Heriwardito A. Neuroprotection role post-surgery patients: controlled trial. Anaesth. pain intensive 2022;26(5):588-594; DOI: 10.35975/apic.v26i5.1985

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ژورنال

عنوان ژورنال: Anaesthesia, pain & intensive care

سال: 2022

ISSN: ['1607-8322', '2220-5799']

DOI: https://doi.org/10.35975/apic.v26i5.1985